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Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator. The original discovery of Substance P (SP) was in 1931 by Ulf von Euler and John H. Gaddum as a tissue extract that caused an intestinal contraction in vitro. Its tissue distribution and biologic actions were further investigated over the following decades.

The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) It belongs to the tachykinin receptor sub-family of GPCRs their neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. Amino acid residues that are responsible for the binding of SP and its antagonists are present in the extracellular loops and transmembrane regions of NK-1. Binding of SP to NK-1 results in internalization by the clathrin-dependent mechanism to the acidified endosomes where the complex disassociates. Subsequently, SP is degraded and NK-1 is re-expressed on the cell surface

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This video tutorial is prepared for pharmacy students and it contains Pharmacology of Substance P.
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